Wind
 

I have a 2012 F-250 King Ranch 4x4. Are you supposed to hear the wind whistling around the doors going down the highway? Sometimes the Sync system can't hear me correctly because of the noise. Seems kind of odd that you pay $50K for a truck and they can't engineer an airtight door...:confused:

My 2011 F250 does the same thing, it sounds like a horn blast at speeds of 70 plus. Not sure where its coming from. anyone have any ideas?

Make sure the door is closed all the way and that the seal around the door is not damaged, and that the window is up tight

Wind
 

Check out the ends of door seals for tight fitting on the frame. If sound is coming even after doing it , then its better to install second set of rubber door seals to bridge any gaps.