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I am new, I have a questions about my F350 Truck Tranny.

Hey Guys.
I am new here, I have an 01 F350 Diesel 7.3L Automatic 2Dr 4x4.

My Question: Tomarrow I have to tow a 6x12' open trailer over 250 miles north of us. Empty is probebly weighs 1,500lbs. Full it may way 5k and change. I drove it home tonight with the empty trailer, turn on the tow/haul switch so the O/D was off.. Rode Like **** Lucky to hit 60mph. I turned it into normal mode drove fine 65-70MPH. Should I have this thing on or off while its empty? and while its full? Please let me know so I dont blow up my tranny.

Jeff